Endocrine Abstracts

Introduction: Ongoing structured education for children and young people with type 1 diabetes and their families is considered essential by ISPAD (2014) and NICE (2015), because there is a lot of education and skills that need to be reinforced.In 2016 the majority of the self-management education was provided at our trust by diabetes self-management education (DSME) sessions, which are two hour sessions designed to improve self-management. This format of...

Objectives: The Diabetes Team at Birmingham Children’s Hospital modified the advanced bolus algorithm suggested by Bell (2015), to develop the KISS (Keep it Simple and Safe). KISS involves adding 25% extra insulin to meals identified as very high fat and protein, and spreading the insulin by a split bolus, 50% now and 50% over 2.5 hours. KISS also has an adjustment tool allowing extra insulin to be added and the split modified from monitoring. KISS is intended to be a sim...

CaseMale, 44 y.o., with rigth maxillary tumor of progressive growth for 1 year with local and low back pain. Imaging exams: CT/MRI skull and face: right axial expansive lesion (62×52×46 mm), heterogeneous, multiloculated with bulging of the right orbit inferomedial wall, with a neoplastic aspect. CT pelvis: bone lesions with soft tissue densities in pelvis, heterogeneous L4, with height reduction. Biopsy of the lesion suggesting a brown tumor. ...

Introduction: The International Society for Paediatric and Adolescent Diabetes (ISPAD) 2022 Nutritional Guidelines recommend calculating carbohydrate requirements using an indivualised equation, such as the Schofield equation. Up to 2023, our centre used the Scientific Advisory Committee on Nutrition (SACN) 2011 guidelines that only require age to determine average carbohydrate requirements. The latest National Paediatric Diabetes Audit (NPDA) showed our centr...

Diabetes Mellitus (DM) has been associated with lung dysfunction and impairment of cardiorespiratory fitness and increasing evidences have suggested that comorbidities and systemic inflammation may be involved in these derangements. However, the results regarding cardiopulmonary dysfunction and its underlying mechanisms in DM are still controversial. In this study, we evaluated the relationship between metabolic variables and inflammation marker, including hemoglobin A1C (HbA1...

Introduction: Melnick Needles Syndrome corresponds to a rare skeletal dysplasia of genetic etiology, with dominant inheritance pattern attached to the X chromosome. Mutations related to the gene of filamina A, which is responsible for the synthesis of collagen, are responsible for the clinical and phenotypic manifestations of the disease, with predominantly female involvement. Rickets are caused by inadequate mineralization of the bone, which precedes the closure of the epiphy...

Introduction: PATRO adults is an international, longitudinal, non-interventional study of the long-term safety and efficacy of recombinant human growth hormone (rhGH; Omnitrope®, Sandoz). The study will provide additional data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here, we present safety data from an interim analysis.Methods: Eligible patients are adults who are receiving treatment with Omnitro...

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

Introduction: More data are needed to confirm the long-term safety of recombinant human GH (rhGH) in adult patients with severe GH deficiency (GHD), particularly with regard to diabetogenic potential. PATRO Adults is an ongoing observational, multicentre, open, longitudinal study of Omnitrope, being conducted in hospitals and specialised endocrinology clinics across Europe. Here, we present safety data from an interim analysis.Methods: Eligible patients ...

Introduction: Sterotactic radiosurgery (SR) has been used to treat recurrent adenomas after failure of medical and surgical procedures and also as a primary treatment. The aim of this paper is to evaluate long-term control of functioning pituitary adenomas (FPA).Patients and method: Thirty-eight patients with FPA treated with modified linear accelerator (LINAC) between 1998 and 2009 in three tertiary Spanish hospitals. Hormonal control was defined as hor...